MilliporeSigma

Percutaneous bone lesion ablation.

La Radiologia medica (2014-06-05)
Dimitrios K Filippiadis, Sean Tutton, Alexis Kelekis
ABSTRACT

Benign tumors and metastatic bone lesions can be treated by ablation techniques performed either alone or in combination with other percutaneous techniques. Ablation techniques include ethanol or acetic acid injection and thermal ablation by means of energy deposition [including laser, radiofrequency, microwave, cryoablation, radiofrequency ionization and magnetic resonance (MR)-guided high-intensity focused ultrasound (HIFU)]. Goal definition of the therapy is crucial: ablation techniques can be proposed as curative treatments in benign bone tumors or oligometastatic disease (<3 lesions). Alternatively, these techniques can be proposed as palliative treatments aiming at reduction of pain, local control of the disease and tumor decompression. Depending on the lesion's location ablation can be combined with cementation with or without further metallic augmentation; local tumor control can be enhanced by combining ablation with transarterial bland embolization or chemoembolization. Thermal ablation of bone and soft tissues is characterized by high success and relatively low rates of potential complications, mainly iatrogenic thermal damage of surrounding sensitive structures. Successful thermal ablation requires a sufficient ablation volume and thermal protection of the surrounding vulnerable structures. This article will describe the general principles governing ablation and the mechanism of action for each technique and in addition will review the literature about safety and effectiveness of percutaneous imaging-guided ablation for benign and malignant (primary and metastatic) lesions.

MATERIALS
Product Number
Brand
Product Description

USP
Dehydrated Alcohol, United States Pharmacopeia (USP) Reference Standard
Sigma-Aldrich
Acetic acid, glacial, puriss. p.a., ACS reagent, reag. ISO, reag. Ph. Eur., ≥99.8%
Sigma-Aldrich
Acetic acid, glacial, puriss., meets analytical specification of Ph. Eur., BP, USP, FCC, 99.8-100.5%
Sigma-Aldrich
Acetic acid solution, suitable for HPLC
Sigma-Aldrich
Acetic acid, glacial, ≥99.99% trace metals basis
Supelco
Ethanol solution, certified reference material, 2000 μg/mL in methanol
Supelco
Dehydrated Alcohol, Pharmaceutical Secondary Standard; Certified Reference Material
Supelco
Ethanol standards 10% (v/v), 10 % (v/v) in H2O, analytical standard
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Ethanol Fixative 80% v/v, suitable for fixing solution (blood films)
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Reagent Alcohol, reagent grade
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Acetic acid, natural, ≥99.5%, FG
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Acetic acid, ≥99.5%, FCC, FG
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Acetic acid, for luminescence, BioUltra, ≥99.5% (GC)
Sigma-Aldrich
Reagent Alcohol, anhydrous, ≤0.003% water
Sigma-Aldrich
Reagent Alcohol, anhydrous, ≤0.005% water
Supelco
Ethanol-400 (10 ampules/kit), 400 mg/dL in H2O, ampule of 10 × 1.2 mL, certified reference material, Cerilliant®
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Reagent Alcohol, suitable for HPLC
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Acetic acid, glacial, ACS reagent, ≥99.7%
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Acetic acid, glacial, ReagentPlus®, ≥99%
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Acetic acid, glacial, puriss., 99-100%
SAFC
Acetic acid, glacial
Supelco
Ethanol-25, 25 mg/dL in H2O, ampule of 10 × 1.2 mL, certified reference material, Cerilliant®
Supelco
Ethanol-20 (10 ampules/kit), 20 mg/dL in H2O, ampule of 10 × 1.2 mL, certified reference material, Cerilliant®
Supelco
Ethanol-500, 500 mg/dL in H2O, ampule of 10 × 1.2 mL, certified reference material, Cerilliant®
Supelco
Ethanol Calibration Kit, ampule of 10 × 1.2 mL, certified reference material, Cerilliant®
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Ethyl alcohol, Pure, 200 proof, anhydrous, ≥99.5%
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Ethyl alcohol, denatured, reagent grade
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Ethyl alcohol, Pure, 190 proof, ACS spectrophotometric grade, 95.0%
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Ethyl alcohol, Pure, 190 proof, meets USP testing specifications
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Ethanol, ACS reagent, prima fine spirit, without additive, F15 o1