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Comment on "Oxytocin-mediated GABA inhibition during delivery attenuates autism pathogenesis in rodent offspring".

Science (New York, N.Y.) (2014-10-11)
Victorio Bambini-Junior, Gustavo Della Flora Nunes, Tomasz Schneider, Carmem Gottfried
ABSTRACT

Tyzio et al. (Reports, 7 February 2014, p. 675) reported that bumetanide restored the impaired oxytocin-mediated γ-aminobutyric acid (GABA) excitatory-inhibitory shift during delivery in animal models of autism, ameliorating some autistic-like characteristics in the offspring. However, standard practices in the study of these models, such as the use of sex-dimorphic or males-only analyses and implementation of tests measuring social behavior, are lacking to definitely associate their findings to autism.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Oxytocin acetate salt hydrate, ≥97% (HPLC)
Sigma-Aldrich
γ-Aminobutyric acid, BioXtra, ≥99%
Sigma-Aldrich
γ-Aminobutyric acid, ≥99%
Supelco
γ-Aminobutyric acid, analytical standard
Vigabatrin impurity D, European Pharmacopoeia (EP) Reference Standard
Sigma-Aldrich
Oxytocin, lyophilized powder, ~15 IU/mg solid (Prepared from synthetic oxytocin)
Sigma-Aldrich
Oxytocin
USP
Oxytocin, United States Pharmacopeia (USP) Reference Standard
Oxytocin, European Pharmacopoeia (EP) Reference Standard