Vanadium-catalyzed pinacol coupling reaction in water.

The Journal of organic chemistry (2005-10-08)
Xiaoliang Xu, Toshikazu Hirao
ABSTRACT

A catalytic pinacol coupling using water as a solvent was performed by a catalytic amount of vanadium(III) chloride and metallic Al as a co-reductant. A combination forms a binary catalytic system, being in sharp contrast to the reaction in organic solvent, which requires a chlorosilane as an additive. Various aromatic aldehydes underwent the reductive coupling to give the corresponding 1,2-diols in moderate to good yields.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Vanadium(III) chloride, 97%