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  • Synthesis of 5-aryl-1,3-dimethyl-6-(alkyl- or aryl-amino) furo [2,3-d]pyrimidine derivatives by reaction between isocyanides and pyridinecarbaldehydes in the presence of 1,3-dimethylbarbituric acid.

Synthesis of 5-aryl-1,3-dimethyl-6-(alkyl- or aryl-amino) furo [2,3-d]pyrimidine derivatives by reaction between isocyanides and pyridinecarbaldehydes in the presence of 1,3-dimethylbarbituric acid.

Molecular diversity (2010-07-14)
Malek Taher Maghsoodlou, Ghasem Marandi, Nourallah Hazeri, Sayyed Mostafa Habibi-Khorassani, Ali Akbar Mirzaei
ABSTRACT

5-Aryl-6-(alkyl- or aryl-amino)-1,3-dimethylfuro [2,3-d]pyrimidine derivatives were obtained by in situ reaction alkyl or aryl isocyanides and pyridinecarbaldehyde derivatives in the presence of 1,3-dimethylbarbituric acid in dichloromethane without any prior activation or modifications.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
1,3-Dimethylbarbituric acid, ≥99.0% (T)

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