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Sequential one-pot bimetallic Ir(III)/Pd(0) catalysed mono-/bis-alkylation and spirocyclisation processes of 1,3-dimethylbarbituric acid and allenes.

Chemical communications (Cambridge, England) (2006-12-06)
Christian Löfberg, Ronald Grigg, Ann Keep, Andrew Derrick, Visuvanathar Sridharan, Colin Kilner
ABSTRACT

Microwave assisted indirect functionalization of alcohols with 1,3-dimethylbarbituric acid followed by spirocyclisation employing a sequential one-pot Ir(III)/Pd(0) catalysed process, involving the formation of three new C-C bonds, one spirocyclic ring and one di- or tri-substituted exocyclic alkene, is described.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
1,3-Dimethylbarbituric acid, ≥99.0% (T)

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