MilliporeSigma
  • Home
  • Search Results
  • Toluidine blue and Lugol's iodine application in the assessment of oral malignant disease and lesions at risk of malignancy.

Toluidine blue and Lugol's iodine application in the assessment of oral malignant disease and lesions at risk of malignancy.

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (1992-04-01)
J B Epstein, C Scully, J Spinelli
ABSTRACT

The purpose of the study was to determine if toluidine blue application and counter staining with Logul's iodine would aid in diagnosis of oral dysplastic or malignant lesions. The sensitivity, specificity, and predictive values were studied. Routine use of these tissue stains was found to be sensitive and specific. The use of stains provided better demarcation of oral squamous cell carcinoma and dysplastic changes and assisted in site selection for diagnostic biopsy. The use of toluidine blue and Lugol's iodine can assist in assessment of patients at risk of developing malignant disease and those with lesions that are clinically suspect of dysplasia or malignancy.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Lugol solution, for microscopy (Bact., Bot.)