Boronate urea activation of nitrocyclopropane carboxylates.

Organic letters (2012-01-03)
Sonia S So, Tyler J Auvil, Victoria J Garza, Anita E Mattson
ABSTRACT

Boronate ureas operate as catalysts for the activation of nitrocyclopropane carboxylates in nucleophilic ring-opening reactions. A variety of amines were found to open the urea-activated nitrocyclopropane carboxylates, generating highly useful nitro ester building blocks in good yields. Standard manipulations allow access to a wide range of valuable compounds from the ring-opened products with direct applications in bioactive target synthesis.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Potassium 3-ethoxycarbonylbenzoyltrifluoroborate
Sigma-Aldrich
Mattson Boronate Urea Pinacol Ester

Social Media

LinkedIn icon
Twitter icon
Facebook Icon
Instagram Icon

MilliporeSigma

Research. Development. Production.

We are a leading supplier to the global Life Science industry with solutions and services for research, biotechnology development and production, and pharmaceutical drug therapy development and production.

© 2021 Merck KGaA, Darmstadt, Germany and/or its affiliates. All Rights Reserved.

Reproduction of any materials from the site is strictly forbidden without permission.