Arylation of diazoesters by a transient N-H insertion organocascade.

Angewandte Chemie (International ed. in English) (2013-09-17)
Tyler J Auvil, Sonia S So, Anita E Mattson
ABSTRACT

It takes two: A unique organocatalyzed cascade for the unsymmetric double arylation of α-nitrodiazoesters is described. This organocascade features the strategic use of carbene-activating anilines in conjunction with a urea catalyst, thus allowing for the synthesis of pharmaceutically attractive α-diarylesters through a transient NH insertion process.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Potassium 3-ethoxycarbonylbenzoyltrifluoroborate
Sigma-Aldrich
Mattson Boronate Urea Pinacol Ester

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