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Chromium VI and stomach cancer: a meta-analysis of the current epidemiological evidence.

Occupational and environmental medicine (2014-09-19)
Roberta Welling, James J Beaumont, Scott J Petersen, George V Alexeeff, Craig Steinmaus
ABSTRACT

Chromium VI (hexavalent chromium, Cr(VI)) is an established cause of lung cancer, but its association with gastrointestinal cancer is less clear. The goal of this study was to examine whether the current human epidemiological research on occupationally inhaled Cr(VI) supports the hypothesis that Cr(VI) is associated with human stomach cancer. Following a thorough literature search and review of individual studies, we used meta-analysis to summarise the current epidemiological literature on inhaled Cr(VI) and stomach cancer, explore major sources of heterogeneity, and assess other elements of causal inference. We identified 56 cohort and case-control studies and 74 individual relative risk (RR) estimates on stomach cancer and Cr(VI) exposure or work in an occupation associated with high Cr(VI) exposure including chromium production, chrome plating, leather work and work with Portland cement. The summary RR for all studies combined was 1.27 (95% CI 1.18 to 1.38). In analyses limited to only those studies identifying increased risks of lung cancer, the summary RR for stomach cancer was higher (RR=1.41, 95% CI 1.18 to 1.69). Overall, these results suggest that Cr(VI) is a stomach carcinogen in humans, which is consistent with the tumour results reported in rodent studies.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Chromium, chips, 99.995% trace metals basis
Sigma-Aldrich
Chromium, powder, ≥99% trace metals basis, <45 μm
Sigma-Aldrich
Chromium, powder, 99.5%, −100 mesh
Sigma-Aldrich
Chromium, chips, thickness ~2 mm, 99.5%
Chromium, rod, 10mm, diameter 5.0mm, 99.7+%
Chromium, foil, light tested, 25x25mm, thickness 0.05mm, permanent polyester support, 99.99+%
Chromium, foil, light tested, 25x25mm, thickness 0.075mm, permanent polyester support, 99.99+%
Chromium, foil, not light tested, 100x100mm, thickness 0.0125mm, permanent polyester support, 99.99+%
Chromium, foil, not light tested, 100x100mm, thickness 0.015mm, permanent polyester support, 99.99+%
Chromium, foil, not light tested, 100x100mm, thickness 0.01mm, permanent polyester support, 99.99+%
Chromium, foil, not light tested, 100x100mm, thickness 0.025mm, permanent polyester support, 99.99+%
Chromium, foil, not light tested, 100x100mm, thickness 0.02mm, permanent polyester support, 99.99+%
Chromium, foil, not light tested, 100x100mm, thickness 0.03mm, permanent polyester support, 99.99+%
Chromium, foil, not light tested, 100x100mm, thickness 0.04mm, permanent polyester support, 99.99+%
Chromium, foil, not light tested, 25x25mm, thickness 0.0015mm, permanent polyester support, 99.99+%
Chromium, foil, not light tested, 25x25mm, thickness 0.001mm, permanent polyester support, 99.99+%
Chromium, foil, not light tested, 25x25mm, thickness 0.0025mm, permanent polyester support, 99.99+%
Chromium, foil, not light tested, 25x25mm, thickness 0.002mm, permanent polyester support, 99.99+%
Chromium, foil, not light tested, 25x25mm, thickness 0.003mm, permanent polyester support, 99.99+%
Chromium, foil, not light tested, 25x25mm, thickness 0.004mm, permanent polyester support, 99.99+%
Chromium, foil, not light tested, 25x25mm, thickness 0.005mm, permanent polyester support, 99.99+%
Chromium, foil, not light tested, 25x25mm, thickness 0.007mm, permanent polyester support, 99.99+%
Chromium, foil, not light tested, 25x25mm, thickness 0.009mm, permanent polyester support, 99.99+%
Chromium, foil, not light tested, 25x25mm, thickness 0.0125mm, permanent polyester support, 99.99+%
Chromium, foil, not light tested, 25x25mm, thickness 0.015mm, permanent polyester support, 99.99+%
Chromium, foil, not light tested, 25x25mm, thickness 0.01mm, permanent polyester support, 99.99+%
Chromium, foil, not light tested, 25x25mm, thickness 0.025mm, permanent polyester support, 99.99+%
Chromium, foil, not light tested, 25x25mm, thickness 0.03mm, permanent polyester support, 99.99+%
Chromium, foil, not light tested, 25x25mm, thickness 0.04mm, permanent polyester support, 99.99+%
Chromium, foil, not light tested, 25x25mm, thickness 0.05mm, permanent polyester support, 99.99+%