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  • Core-shell-type magnetic mesoporous silica nanocomposites for bioimaging and therapeutic agent delivery.

Core-shell-type magnetic mesoporous silica nanocomposites for bioimaging and therapeutic agent delivery.

Advanced materials (Deerfield Beach, Fla.) (2014-09-23)
Yao Wang, Hongchen Gu
ABSTRACT

Advances in nanotechnology and nanomedicine offer great opportunities for the development of nanoscaled theranostic platforms. Among various multifunctional nanocarriers, magnetic mesoporous silica nanocomposites (M-MSNs) attract prominent research interest for their outstanding properties and potential biomedical applications. This Research News article highlights recent progress in the design of core-shell-type M-MSNs for both diagnostic and therapeutic applications. First, an overview of synthetic strategies for three representative core-shell-type M-MSNs with different morphologies and structures is presented. Then, the diagnostic functions of M-MSNs is illustrated for magnetic resonance imaging (MRI) applications. Next, magnetic targeted delivery and stimuli-responsive release of drugs, and effective package of DNA/siRNA inside mesopores using M-MSNs as therapeutic agent carriers are discussed. The article concludes with some important challenges that need to be overcome for further practical applications of M-MSNs in nanomedicine.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Silica, mesoporous SBA-15, <150 μm particle size, pore size 12 nm, Hexagonal pore morphology
Sigma-Aldrich
Silica, mesoporous, 200 nm particle size, pore size ~2 nm
Sigma-Aldrich
Silica, mesoporous, 1 μm particle size, pore size ~2 nm