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  • Deferoxamine compensates for decreases in B cell counts and reduces mortality in enterovirus 71-infected mice.

Deferoxamine compensates for decreases in B cell counts and reduces mortality in enterovirus 71-infected mice.

Marine drugs (2014-07-09)
Yajun Yang, Jing Ma, Jinghui Xiu, Lin Bai, Feifei Guan, Li Zhang, Jiangning Liu, Lianfeng Zhang
ABSTRACT

Enterovirus 71 is one of the major causative agents of hand, foot and mouth disease in children under six years of age. No vaccine or antiviral therapy is currently available. In this work, we found that the number of B cells was reduced in enterovirus 71-infected mice. Deferoxamine, a marine microbial natural product, compensated for the decreased levels of B cells caused by enterovirus 71 infection. The neutralizing antibody titer was also improved after deferoxamine treatment. Furthermore, deferoxamine relieved symptoms and reduced mortality and muscle damage caused by enterovirus 71 infection. This work suggested that deferoxamine has the potential for further development as a B cell-immunomodulator against enterovirus 71.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Methanesulfonic acid, ≥99.0%
Supelco
Methanesulfonic acid, suitable for HPLC, LiChropur, ≥99.5% (T)
Supelco
Methanesulfonic acid concentrate, 0.1 M CH3SO3H in water (0.1N), eluent concentrate for IC
Sigma-Aldrich
Methanesulfonic acid solution, 70 wt. % in H2O
Sigma-Aldrich
Methanesulfonic acid solution, 4 M (with 0.2% (w/v) tryptamine)