MilliporeSigma
  • Home
  • Search Results
  • miR-150 functions as a tumour suppressor in human colorectal cancer by targeting c-Myb.

miR-150 functions as a tumour suppressor in human colorectal cancer by targeting c-Myb.

Journal of cellular and molecular medicine (2014-09-19)
Junlan Feng, Yongzhi Yang, Peng Zhang, Feng Wang, Yanlei Ma, Huanlong Qin, Yu Wang
ABSTRACT

Our previously published study documented a deregulation of the microRNA miR-150 in colorectal cancer. Here, we investigated further, in vitro and in vivo, the potential molecular mechanisms underlying the involvement of miR-150 in colorectal cancer, using the appropriate molecular biological methods. We report that miR-150 is a key regulator in the tumourigenesis and progression of colorectal cancer, by acting as a tumour suppressor targeting c-Myb. The current findings suggest that miR-150 may have important roles in the pathogenesis of colorectal cancer.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
MISSION® esiRNA, targeting human CHN1
Sigma-Aldrich
MISSION® esiRNA, targeting mouse Chn1