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Locomotor-reducing effects and structural characteristics of inhaled zerumbone and tetrahydrozerumbone derivatives.

Biological & pharmaceutical bulletin (2014-09-02)
Kakuyou Ogawa, Takashi Miyoshi, Takashi Kitayama, Michiho Ito
ABSTRACT

Zerumbone 1 is an 11-membered cyclic sesquiterpene obtained from the rhizomes of Zingiber zerumbet SMITH (Zingiberaceae). In this study, we investigated the structure-activity relationship of 1, α-humulene (2), tetrahydrozerumbone stereoisomers (3-5), and tetrahydrozerumbone derivatives (6-9). The oxygen-containing functional groups and the configurations at C1 and C2 contributed to the spontaneous locomotor activity reduction of zerumbone 1 and derivatives 2-9.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Triethyl citrate, ≥99%, FCC, FG
Sigma-Aldrich
Triethyl citrate, ≥98.0% (GC)
Supelco
Triethyl citrate, analytical standard
Supelco
Triethyl citrate, Pharmaceutical Secondary Standard; Certified Reference Material