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Preventing bacterial growth on implanted device with an interfacial metallic film and penetrating X-rays.

Journal of materials science. Materials in medicine (2015-01-30)
Jincui An, An Sun, Yong Qiao, Peipei Zhang, Ming Su
ABSTRACT

Device-related infections have been a big problem for a long time. This paper describes a new method to inhibit bacterial growth on implanted device with tissue-penetrating X-ray radiation, where a thin metallic film deposited on the device is used as a radio-sensitizing film for bacterial inhibition. At a given dose of X-ray, the bacterial viability decreases as the thickness of metal film (bismuth) increases. The bacterial viability decreases with X-ray dose increases. At X-ray dose of 2.5 Gy, 98% of bacteria on 10 nm thick bismuth film are killed; while it is only 25% of bacteria are killed on the bare petri dish. The same dose of X-ray kills 8% fibroblast cells that are within a short distance from bismuth film (4 mm). These results suggest that penetrating X-rays can kill bacteria on bismuth thin film deposited on surface of implant device efficiently.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Bismuth, granular, ≥99.99% trace metals basis
Sigma-Aldrich
Bismuth, powder, −100 mesh, ≥99.99% trace metals basis
Sigma-Aldrich
Bismuth, pieces, 1-12 mm, 99.999% trace metals basis
Sigma-Aldrich
Bismuth, shot, 4-30 mesh, 99.9% trace metals basis
Sigma-Aldrich
Bismuth, powder, −100 mesh, 99% trace metals basis
Sigma-Aldrich
Bismuth, beads, 1-5 mm, 99.999% trace metals basis
Bismuth, foil, not light tested, 50x50mm, thickness 0.02mm, permanent polyester support, 99.97%
Bismuth, foil, light tested, 25x25mm, thickness 0.015mm, permanent polyester support, 99.97%
Bismuth, foil, not light tested, 25x25mm, thickness 0.001mm, permanent polyester support, 99.97%
Bismuth, foil, not light tested, 25x25mm, thickness 0.02mm, permanent polyester support, 99.97%
Bismuth, foil, not light tested, 100x100mm, thickness 0.02mm, permanent polyester support, 99.97%
Bismuth, foil, not light tested, 100x100mm, thickness 0.05mm, permanent polyester support, 99.97%
Bismuth, foil, not light tested, 50x50mm, thickness 0.0025mm, permanent polyester support, 99.97%
Bismuth, foil, not light tested, 25x25mm, thickness 0.025mm, permanent polyester support, 99.97%
Bismuth, foil, light tested, 25x25mm, thickness 0.05mm, permanent polyester support, 99.97%
Bismuth, foil, 25x25mm, thickness 2.0mm, 100%
Bismuth, foil, light tested, 50x50mm, thickness 0.015mm, permanent polyester support, 99.97%
Bismuth, foil, not light tested, 150x150mm, thickness 0.05mm, permanent polyester support, 99.97%
Bismuth, foil, not light tested, 50x50mm, thickness 0.001mm, permanent polyester support, 99.97%
Bismuth, foil, light tested, 25x25mm, thickness 0.02mm, permanent polyester support, 99.97%
Bismuth, foil, light tested, 25x25mm, thickness 0.01mm, permanent polyester support, 99.97%
Bismuth, foil, not light tested, 25x25mm, thickness 0.0025mm, permanent polyester support, 99.97%
Bismuth, foil, 50x50mm, thickness 0.25mm, 100%
Bismuth, foil, not light tested, 50x50mm, thickness 0.005mm, permanent polyester support, 99.97%
Bismuth, foil, 25x25mm, thickness 1.0mm, 100%
Bismuth, foil, not light tested, 100x100mm, thickness 0.01mm, permanent polyester support, 99.97%
Bismuth, foil, 25x25mm, thickness 0.5mm, 100%
Bismuth, foil, not light tested, 50x50mm, thickness 0.05mm, permanent polyester support, 99.97%
Bismuth, foil, not light tested, 150x150mm, thickness 0.02mm, permanent polyester support, 99.97%
Bismuth, foil, 50x50mm, thickness 1.0mm, 99.97%