MilliporeSigma
  • Home
  • Search Results
  • Synthesis and characterization of a novel water-soluble cationic diblock copolymer with star conformation by ATRP.

Synthesis and characterization of a novel water-soluble cationic diblock copolymer with star conformation by ATRP.

Materials science & engineering. C, Materials for biological applications (2014-09-02)
Shuzhao Li, Miaomiao Xiao, Anna Zheng, Huining Xiao
ABSTRACT

A water-soluble cationic diblock copolymer, CD-PAM-b-PMeDMA, was synthesized through atom transfer radical polymerization (ATRP) from a β-cyclodextrin (CD) macroinitiator with 10-active sites (10Br-β-CD). In order to reduce the cytotoxicity of the CD-PAM-b-PMeDMA, biocompatible polyacrylamide (PAM) was first introduced onto the surface of β-CD as a scaffold structure by ATRP using the 10Br-β-CD as a macroinitiator. The reaction conditions of AM were explored and optimized. The ATRP of [2-(methacryloyloxy)ethyl] trimethyl ammonium chloride (MeDMA) was also performed to synthesize the second cationic block using the resulting CD-PAM as a macroinitiator. The resulting diblock copolymer shows an increased hydrodynamic radius in aqueous solution with a pretty low concentration compared with β-CD. In addition, it appears a near-uniform coniform after being deposited on mica ascribed to the presence of an asymmetric 10-arm structure.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Acrylamide solution, 40%, suitable for electrophoresis, sterile-filtered
Sigma-Aldrich
Pyridine, anhydrous, 99.8%
Sigma-Aldrich
Trimethylamine hydrochloride, 98%
Supelco
Acrylamide solution, 40% in H2O, for molecular biology
Sigma-Aldrich
4-(Dimethylamino)pyridine, purum, ≥98.0% (NT)
Supelco
Pyridine, analytical standard
Sigma-Aldrich
2,2′-Bipyridyl, ReagentPlus®, ≥99%
Sigma-Aldrich
Pyridine, ≥99%
Sigma-Aldrich
α-Bromoisobutyryl bromide, 98%
Sigma-Aldrich
4-(Dimethylamino)pyridine, ReagentPlus®, ≥99%
Sigma-Aldrich
N,N,N′,N′′,N′′-Pentamethyldiethylenetriamine, 99%
Supelco
Pyridine, Pharmaceutical Secondary Standard; Certified Reference Material
Sigma-Aldrich
Pyridine, ReagentPlus®, ≥99%
Sigma-Aldrich
Pyridine, ACS reagent, ≥99.0%
Sigma-Aldrich
Pyridine, suitable for HPLC, ≥99.9%
Sigma-Aldrich
Pyridine, puriss. p.a., ACS reagent, reag. Ph. Eur., ≥99.5% (GC)
Sigma-Aldrich
Pyridine, ReagentPlus®, ≥99%
Sigma-Aldrich
Pyridine, biotech. grade, ≥99.9%
Supelco
Trimethylamine hydrochloride, analytical standard
Sigma-Aldrich
Pyridine, ACS reagent, ≥99.0%
Sigma-Aldrich
Acrylamide, for molecular biology, ≥99% (HPLC)
Sigma-Aldrich
Acrylamide, suitable for electrophoresis, ≥99%
Sigma-Aldrich
Acrylamide, suitable for electrophoresis, ≥99% (HPLC), powder
Sigma-Aldrich
Triethylamine, ≥99%
Sigma-Aldrich
Triethylamine, BioUltra, ≥99.5% (GC)
Sigma-Aldrich
Acrylamide, purum, ≥98.0% (GC)
Sigma-Aldrich
Triethylamine, for protein sequence analysis, ampule, ≥99.5% (GC)
Sigma-Aldrich
Triethylamine, puriss. p.a., ≥99.5% (GC)
Sigma-Aldrich
Triethylamine, for amino acid analysis, ≥99.5% (GC)
Sigma-Aldrich
Acrylamide, for Northern and Southern blotting, powder blend