Senescence and p130/Rbl2: a new beginning to the end.

Cell research (2009-08-12)
Francesco P Fiorentino, Catherine E Symonds, Marcella Macaluso, Antonio Giordano
ABSTRACT

Senescence is the process of cellular aging dependent on the normal physiological functions of non-immortalized cells. With increasing data being uncovered in this field, the complex molecular web regulating senescence is gradually being unraveled. Recent studies have suggested two main phases of senescence, the triggering of senescence and the maintenance of senescence. Each has been supported by data implying precise roles for DNA methyltransferases, reactive oxygen species and other factors. We will first summarize the data supporting these claims and then highlight the specific role that we hypothesize that p130/Rbl2 plays in the modulation of the senescence process.

MATERIALS
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Product Description

Sigma-Aldrich
Anti-RBL2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

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