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Identification of the Polyketide Biosynthetic Machinery for the Indolizidine Alkaloid Cyclizidine.

Organic letters (2015-10-17)
Wei Huang, Seong Jong Kim, Joyce Liu, Wenjun Zhang
ABSTRACT

The cyclizidine biosynthetic gene cluster was identified from Streptomyces NCIB 11649, which revealed the polyketide biosynthetic machinery for cyclizidine alkaloid biosynthesis. Both in vivo mutagenesis study and in vitro biochemical analysis provided insight into the timing and mechanism of the biosynthetic enzymes that produce cyclizidine-type indolizidine alkaloids.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
DL-Tyrosine, 99%
Sigma-Aldrich
DL-Phenylalanine, ReagentPlus®, 99%