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Preclinical evaluation of (99m)Tc labeled gefitinib as a potential scintigraphic probe for the detection of tumors expressing epidermal growth factor receptors.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine (2015-02-24)
Pardeep Kumar, Baljinder Singh, Anchal Ghai, Krishna Chuttani, Devinder Dhawan, Bhagwant R Mittal, Anil K Mishra
ABSTRACT

In the present study, we successfully radiolabeled gefitinib with (99m)Tc by direct labeling method. The radio-ligand had radiolabeling efficiency of >95.0% and in vitro stability of >80.0% at 24h. The radiotracer cleared from blood bi-exponentially. Animal organ biodistribution data indicated hepato-renal excretion of the radiotracer. Scintigraphy carried out in tumor bearing mice (induced by EGFR expressing EAT cell lines) demonstrated that the radiotracer accumulated in the tumor site with T/NT ratio of 3.3±0.2 at 1h.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Tin(II) chloride dihydrate, ≥99.995% trace metals basis
Sigma-Aldrich
Tin(II) chloride dihydrate, ≥99.99% trace metals basis