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Fast Identification of 1,3-Dimethylamylamine Using Direct Analysis in Real Time-QToF-MS.

Journal of AOAC International (2015-06-19)
Bharathi Avula, Troy J Smillie, Yan-Hong Wang, Jerry Zweigenbaum, Mahmoud A ElSohly, Ikhlas A Khan
ABSTRACT

The central nervous system stimulant 1,3-dimethylamylamine (DMAA) has been found in preworkout products and dietary supplements. A fast direct analysis in real time-quadrupole time of flight-MS method was used for identification of DMAA in dietary supplements and to determine if this compound is present in geranium (Pelargonium graveolens) plants or oil. This method involved the use of [M+H]+ ions in the positive mode based on the exact mass of DMAA. The results of this investigation showed that DMAA was not detected from authentic samples of P. graveolens plant material or pelargonium oil or in multiple samples of commercially available pelargonium oil. DMAA was detected in three samples of dietary supplements. The LOD of DMAA was found to be 10 ng/mL.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
N,N-Dimethylacetoacetamide solution, 80% in H2O
Sigma-Aldrich
N,N-Dimethylacetoacetamide solution, Lonza quality, 79.0-83.0% (calculated)