• Home
  • Search Results
  • Zinc overload enhances APP cleavage and Aβ deposition in the Alzheimer mouse brain.

Zinc overload enhances APP cleavage and Aβ deposition in the Alzheimer mouse brain.

PloS one (2010-12-24)
Chun-Yan Wang, Tao Wang, Wei Zheng, Bao-Lu Zhao, Gorm Danscher, Yu-Hua Chen, Zhan-You Wang

Abnormal zinc homeostasis is involved in β-amyloid (Aβ) plaque formation and, therefore, the zinc load is a contributing factor in Alzheimer's disease (AD). However, the involvement of zinc in amyloid precursor protein (APP) processing and Aβ deposition has not been well established in AD animal models in vivo. In the present study, APP and presenilin 1 (PS1) double transgenic mice were treated with a high dose of zinc (20 mg/ml ZnSO4 in drinking water). This zinc treatment increased APP expression, enhanced amyloidogenic APP cleavage and Aβ deposition, and impaired spatial learning and memory in the transgenic mice. We further examined the effects of zinc overload on APP processing in SHSY-5Y cells overexpressing human APPsw. The zinc enhancement of APP expression and cleavage was further confirmed in vitro. The present data indicate that excess zinc exposure could be a risk factor for AD pathological processes, and alteration of zinc homeostasis is a potential strategy for the prevention and treatment of AD.

Product Number
Product Description

Anti-Amyloid Precursor Protein, C-Terminal antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution
Monoclonal Anti-β-Amyloid antibody produced in mouse, clone BAM-10, ascites fluid
Anti-BACE 1, N-Terminus (46-62) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution
Anti-ADAM 10 Antibody, CT, Chemicon®, from rabbit
Anti-Presenilin-1 Antibody, NT, clone hPS1-NT, culture supernatant, clone hPS1-NT, Chemicon®
Anti-Amyloid Precursor Protein Antibody, CT, serum, Chemicon®

Social Media

LinkedIn icon
Twitter icon
Facebook Icon
Instagram Icon


Research. Development. Production.

We are a leading supplier to the global Life Science industry with solutions and services for research, biotechnology development and production, and pharmaceutical drug therapy development and production.

© 2021 Merck KGaA, Darmstadt, Germany and/or its affiliates. All Rights Reserved.

Reproduction of any materials from the site is strictly forbidden without permission.