S-chiral sulfinamides as highly enantioselective organocatalysts.

Organic letters (2006-12-01)
Dong Pei, Zhouyu Wang, Siyu Wei, Yu Zhang, Jian Sun
ABSTRACT

Easily accessible chiral sulfinamide 2 has been developed as the first highly efficient and enantioselective organocatalyst relying solely on a chiral sulfur center for stereochemical induction. In the presence of 20 mol % of 2, a broad range of N-aryl ketimines 1 were reduced by trichlorosilane to produce amines 3 in high yield and enantioselectivity. [reaction: see text]

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
(R)-(+)-2-Methyl-2-propanesulfinamide, 98%

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