• Home
  • Search Results
  • Cu(I)-catalyzed reductive aldol cyclizations: diastereo- and enantioselective synthesis of beta-hydroxylactones.

Cu(I)-catalyzed reductive aldol cyclizations: diastereo- and enantioselective synthesis of beta-hydroxylactones.

Organic letters (2005-09-09)
Hon Wai Lam, Pekka M Joensuu
ABSTRACT

[reaction: see text] Copper bisphosphine complexes catalyze the intramolecular reductive aldol reaction of alpha,beta-unsaturated esters with ketones, affording five- and six-membered beta-hydroxylactones in high stereoselectivities. Utilization of chiral nonracemic bisphosphines render the cyclizations enantioselective.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
4-Hydroxy-2-butanone, 95%