Torque-actuated valves for microfluidics.

Analytical chemistry (2005-08-02)
Douglas B Weibel, Maarten Kruithof, Scott Potenta, Samuel K Sia, Andrew Lee, George M Whitesides
ABSTRACT

This paper describes torque-actuated valves for controlling the flow of fluids in microfluidic channels. The valves consist of small machine screws (> or =500 microm) embedded in a layer of polyurethane cast above microfluidic channels fabricated in poly(dimethylsiloxane) (PDMS). The polyurethane is cured photochemically with the screws in place; on curing, it bonds to the surrounding layer of PDMS and forms a stiff layer that retains an impression of the threads of the screws. The valves were separated from the ceiling of microfluidic channels by a layer of PDMS and were integrated into channels using a simple procedure compatible with soft lithography and rapid prototyping. Turning the screws actuated the valves by collapsing the PDMS layer between the valve and channel, controlling the flow of fluids in the underlying channels. These valves have the useful characteristic that they do not require power to retain their setting (on/off). They also allow settings between "on" and "off" and can be integrated into portable, disposable microfluidic devices for carrying out sandwich immunoassays.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Anti-Human IgA (α-chain specific)−Alkaline Phosphatase antibody produced in goat, affinity isolated antibody, buffered aqueous solution
Sigma-Aldrich
Anti-Human Polyvalent Immunoglobulins (G,A,M) antibody produced in goat, whole antiserum

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