A new picornavirus isolated from bank voles (Clethrionomys glareolus).

Virology (1999-03-02)
B Niklasson, L Kinnunen, B Hörnfeldt, J Hörling, C Benemar, K O Hedlund, L Matskova, T Hyypiä, G Winberg
ABSTRACT

A previously unknown picornavirus was isolated from bank voles (Clethrionomys glareolus). Electron microscopy images and sequence data of the prototype isolate, named Ljungan virus, showed that it is a picornavirus. The amino acid sequences of predicted Ljungan virus capsid proteins VP2 and VP3 were closely related to the human pathogen echovirus 22 (approximately 70% similarity). A partial 5' noncoding region sequence of Ljungan virus showed the highest degree of relatedness to cardioviruses. Two additional isolates were serologically and molecularly related to the prototype.

MATERIALS
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Sigma-Aldrich
Anti-Human IgG (γ-chain specific), F(ab′)2 fragment–FITC antibody produced in goat, affinity isolated antibody, buffered aqueous solution

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