Matrigel: basement membrane matrix with biological activity.

Seminars in cancer biology (2005-06-25)
Hynda K Kleinman, George R Martin
ABSTRACT

The basement membrane extracellular matrix contacts epithelial, endothelial, fat and smooth muscle cells. Because this extracellular matrix is so thin, it had been hard to study its composition, structure, and function. An extract of a tumor was found to contain all of the components present in basement and to be very biologically active. This extract, termed Matrigel, Cultrex, or EHS matrix, promotes cell differentiation, and is used to measure the invasive activity of tumor cells. In vivo, it is used for measuring angiogenic inhibitors and stimulators, to improve graft survival, repair damaged tissues, and increase tumor growth.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Laminin from Engelbreth-Holm-Swarm murine sarcoma basement membrane, 1-2 mg/mL in Tris-buffered saline, 0.2 μm filtered, BioReagent, suitable for cell culture
Sigma-Aldrich
ECM Gel from Engelbreth-Holm-Swarm murine sarcoma, liquid, BioReagent, suitable for cell culture
Sigma-Aldrich
ECM Gel from Engelbreth-Holm-Swarm murine sarcoma, growth-factor reduced, without phenol red, liquid, BioReagent, suitable for cell culture
Sigma-Aldrich
Stem Cell Qualified ECM Gel, Stem cell qualified basement membrane extract (BME) for human ES and iPS cell culture.
Sigma-Aldrich
PureCol EZ Gel solution