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The minor histocompatibility antigen HA-1: a diallelic gene with a single amino acid polymorphism.

Science (New York, N.Y.) (1998-03-07)
J M den Haan, L M Meadows, W Wang, J Pool, E Blokland, T L Bishop, C Reinhardus, J Shabanowitz, R Offringa, D F Hunt, V H Engelhard, E Goulmy
ABSTRACT

The minor histocompatibility antigen (mHag) HA-1 is the only known mHag for which mismatching is correlated with the development of severe graft versus host disease (GvHD) after human leukocyte antigen-identical bone marrow transplantation. HA-1 was found to be a nonapeptide derived from an allele of the KIAA0223 gene. The HA-1-negative allelic counterpart encoded by KIAA0223 had one amino acid difference from HA-1. Family analysis with HA-1 allele-specific polymerase chain reaction showed an exact correlation between this allelic polymorphism and the HA-1 phenotype. HA-1 allele typing of donor and recipient should improve donor selection and allow the determination of bone marrow transplantation recipients with high risk for HA-1-induced GvHD development.