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ERBB2 Is Essential for the Growth of Chemically Induced Skin Tumors in Mice.

The Journal of investigative dermatology (2016-12-10)
Maik Dahlhoff, Sukalp Muzumdar, Matthias Schäfer, Marlon R Schneider
ABSTRACT

Although the epidermal growth factor receptor has established roles in skin carcinogenesis, inflammation, and wound healing, the functions of the structurally related receptor ERBB2 in this tissue remain poorly explored. To assess the functions of ERBB2 in skin homeostasis, tumorigenesis, and wound healing, we employed keratin 5-directed, cre recombinase-mediated targeting of Erbb2 alleles in mice. Erbb2

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