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Osteopontin has a protective role in prostate tumor development in mice.

European journal of immunology (2016-11-05)
Keiko Danzaki, Masashi Kanayama, Oscar Alcazar, Mari L Shinohara
ABSTRACT

Osteopontin (OPN) is a protein, generally considered to play a pro-tumorigenic role, whereas several reports have demonstrated the anti-tumorigenic function of OPN during tumor development. These opposing anti- and pro-tumorigenic functions are not fully understood. Here, we report that host-derived OPN plays an anti-tumorigenic role in the transgenic adenocarcinoma of the mouse prostate (TRAMP) model and a TRAMP tumor transplant model. Tumor suppression mediated by OPN in Rag2

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Product Description

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