Cytoskeletal proteins talin and vinculin in integrin-mediated adhesion.

Biochemical Society transactions (2004-10-21)
D R Critchley
ABSTRACT

The cytoskeletal proteins talin and vinculin form part of a macromolecular complex on the cytoplasmic face of integrin-mediated cellular junctions with the extracellular matrix. Recent genetic, biochemical and structural data show that talin is essential for the assembly of such junctions, whereas vinculin appears to be important in regulating adhesion dynamics and cell migration.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Monoclonal Anti-Talin antibody produced in mouse, clone 8d4, ascites fluid
Sigma-Aldrich
Anti-Talin antibody,Mouse monoclonal, clone TA205, purified from hybridoma cell culture