MilliporeSigma
  • Home
  • Search Results
  • The role of steroids in the prediction of affective disorders in adult men.

The role of steroids in the prediction of affective disorders in adult men.

Steroids (2016-11-23)
Monika Šrámková, Michaela Dušková, Martin Hill, Marie Bičíková, Daniela Řípová, Pavel Mohr, Luboslav Stárka
ABSTRACT

Anxiety and mood disorders (AMD) are the most frequent mental disorders in the human population. They have recently shown increasing prevalence, and commonly disrupt personal and working lives. The aim of our study was to analyze the spectrum of circulating steroids in order to discover differences that could potentially be markers of affective depression or anxiety, and identify which steroids could be a predictive component for these diseases. We studied the steroid metabolome including 47 analytes in 20 men with depression (group D), 20 men with anxiety (group AN) and 30 healthy controls. OPLS and multivariate regression models were used for statistical analysis. Discrimination of group D from controls by the OPLS method was absolute, as was group AN from controls (sensitivity=1.000 (0.839, 1.000), specificity=1.000 (0.887, 1.000)). Relatively good predictivity was also found for discrimination between group D from AN (sensitivity=0.850 (0.640, 0.948), specificity=0.900 (0.699, 0.972)). Selected circulating steroids, including those that are neuroactive and neuroprotective, can be useful tools for discriminating between these affective diseases in adult men.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
5β-Pregnan-3α-ol-20-one
Sigma-Aldrich
5α-Pregnan-3α-ol-20-one, solid
Supelco
Androsterone, VETRANAL®, analytical standard
Sigma-Aldrich
trans-Androsterone
Sigma-Aldrich
5-Pregnen-3β-ol-20-one, ≥98%