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Inhalable Ipratropium Bromide Particle Engineering with Multicriteria Optimization.

AAPS PharmSciTech (2016-11-23)
Bhavani Prasad Vinjamuri, Rahul V Haware, William C Stagner
ABSTRACT

Spray-dried ipratropium bromide (IPB) microspheres for oral inhalation were engineered using Quality by Design. The interrogation of material properties, process parameters, and critical product quality attributes interplay enabled rational product design. A 2

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Tetrapropylammonium chloride, 98%