• Home
  • Search Results
  • Studies on cyclization reactions of 3-amino-2,4-dihydroxybutanoic acid derivatives.

Studies on cyclization reactions of 3-amino-2,4-dihydroxybutanoic acid derivatives.

Organic & biomolecular chemistry (2017-01-21)
Mathieu Esgulian, Vincent Belot, Régis Guillot, Sandrine Deloisy, David J Aitken
ABSTRACT

A number of cyclic derivatives of 3-amino-2,4-dihydroxybutanoic acid are known in the literature but they are often prepared from other cyclic precursors. This study showed that the title compound too may serve as a convenient substrate for cyclization reactions. Using orthogonally-protected linear derivatives, regioselective cyclizations were performed, leading to original and highly-functionalized γ-lactones, oxazolidinones, oxazolines and aziridines. In these reactions a key role was played by the C3 nitrogen group function, while the C2 alcohol function showed no propensity for participation in cyclization reactions.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
2-Oxazolidinone, 98%

Social Media

LinkedIn icon
Twitter icon
Facebook Icon
Instagram Icon

MilliporeSigma

Research. Development. Production.

We are a leading supplier to the global Life Science industry with solutions and services for research, biotechnology development and production, and pharmaceutical drug therapy development and production.

© 2021 Merck KGaA, Darmstadt, Germany and/or its affiliates. All Rights Reserved.

Reproduction of any materials from the site is strictly forbidden without permission.