CD206

Nature communications (2017-08-19)
Allah Nawaz, Aminuddin Aminuddin, Tomonobu Kado, Akiko Takikawa, Seiji Yamamoto, Koichi Tsuneyama, Yoshiko Igarashi, Masashi Ikutani, Yasuhiro Nishida, Yoshinori Nagai, Kiyoshi Takatsu, Johji Imura, Masakiyo Sasahara, Yukiko Okazaki, Kohjiro Ueki, Tadashi Okamura, Kumpei Tokuyama, Akira Ando, Michihiro Matsumoto, Hisashi Mori, Takashi Nakagawa, Norihiko Kobayashi, Kumiko Saeki, Isao Usui, Shiho Fujisaka, Kazuyuki Tobe
ABSTRACT

Adipose tissue resident macrophages have important roles in the maintenance of tissue homeostasis and regulate insulin sensitivity for example by secreting pro-inflammatory or anti-inflammatory cytokines. Here, we show that M2-like macrophages in adipose tissue regulate systemic glucose homeostasis by inhibiting adipocyte progenitor proliferation via the CD206/TGFβ signaling pathway. We show that adipose tissue CD206

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Collagenase from Clostridium histolyticum, suitable for release of physiologically active rat epididymal adipocytes, Type II, 0.5-5.0 FALGPA units/mg solid, ≥125 CDU/mg solid
Sigma-Aldrich
Diphtheria Toxin from Corynebacterium diphtheriae, lyophilized powder, Product is in unnicked form