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  • Fluorometric probing of the lipase level as acute pancreatitis biomarkers based on interfacially controlled aggregation-induced emission (AIE).

Fluorometric probing of the lipase level as acute pancreatitis biomarkers based on interfacially controlled aggregation-induced emission (AIE).

Chemical science (2017-10-11)
Jie Shi, Qianchun Deng, Chuyun Wan, Mingming Zheng, Fenghong Huang, Bo Tang
ABSTRACT

As a sudden inflammation of the pancreas, acute pancreatitis presents severe complications and a high mortality rate, despite treatment. Lipase in serum serves as an essential biomarker of acute pancreatitis and even pancreatic cancer. Therefore, developing robust, convenient and sensitive probing of lipase levels is greatly needed. In this work, we present glutamate functionalized tetraphenylethylene (TPE) as a "turn-on" fluorescent probe (

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Boc-Glu-OtBu
Sigma-Aldrich
Boc-Glu-OH, ≥98.0% (T)
Sigma-Aldrich
1,3-Propylene sulfite, 99%
Sigma-Aldrich
4-Hydroxybenzophenone, 98%