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Improved metabolic stability and therapeutic efficacy of a novel molecular gemcitabine phospholipid complex.

International journal of pharmaceutics (2017-07-26)
Chander Parkash Dora, Varun Kushwah, Sameer S Katiyar, Pradeep Kumar, Viness Pillay, Sarasija Suresh, Sanyog Jain
ABSTRACT

The aim of the present research is to increase lipid solubility, metabolic stability and therapeutic efficacy of water soluble gemcitabine (GEM) via phospholipid complex (PC) formation. A novel phospholipid complex of GEM was successfully prepared and optimized. Physical interaction of GEM with phospholipid was evaluated by DSC, FT-IR,

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6-Carboxyfluorescein diacetate, ~95% (HPLC)