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Antenatal/early postnatal hypothyroidism alters arterial tone regulation in 2-week-old rats.

The Journal of endocrinology (2017-08-11)
Svetlana I Sofronova, Dina K Gaynullina, Anastasia A Shvetsova, Anna A Borzykh, Ekaterina K Selivanova, Daria S Kostyunina, Anna P Sharova, Andrey A Martyanov, Olga S Tarasova
ABSTRACT

The mechanisms of vascular alterations resulting from early thyroid hormones deficiency are poorly understood. We tested the hypothesis that antenatal/early postnatal hypothyroidism would alter the activity of endothelial NO pathway and Rho-kinase pathway, which are specific for developing vasculature. Dams were treated with propylthiouracil (PTU, 7 ppm) in drinking water during gestation and 2 weeks after delivery, and their progeny had normal body weight but markedly reduced blood levels of thyroid hormones (ELISA). Small arteries from 2-week-old male pups were studied using wire myography, qPCR and Western blotting. Mesenteric arteries of PTU pups, compared to controls, demonstrated smaller maximum response to α

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Cyclohexanecarboxamide, 97%
Sigma-Aldrich
5-Propyl-2-thiouracil, ≥98%

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