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  • Photodegradation of prednisolone under UVB solar irradiation. Role of photogenerated ROS in the degradation mechanism.

Photodegradation of prednisolone under UVB solar irradiation. Role of photogenerated ROS in the degradation mechanism.

Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology (2017-10-27)
R Daniel Cacciari, Eugenia Reynoso, Hernán A Montejano, M Alicia Biasutti
ABSTRACT

The use of biologically active substances with anti-inflammatory properties such as corticosteroids has increased considerably in the last few decades. Particularly, the compound we are interested in, prednisolone (Predn), is a glucocorticoid with high biological activity. This compound absorbs UV radiation and may participate in photochemical processes, which can result in its own decomposition. These processes could result in the formation of free radicals or reactive oxygen species (ROS). On these grounds, the kinetic and mechanistic aspects of the direct photodegradation of Predn have been studied in aqueous medium under different atmospheric conditions by stationary and time-resolved techniques. The mechanism involved in the photodegradation has been elucidated. Predn is capable of generating the excited triplet state

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