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Phenotypic Screen Identifies a Small Molecule Modulating ERK2 and Promoting Stem Cell Proliferation.

Frontiers in pharmacology (2017-11-09)
Chang Yin, Temesgen Fufa, Gayathri Chandrasekar, Madhu Aeluri, Verina Zaky, Shaimaa Abdelhady, Antonio B Rodríguez, Johan Jakobsson, Farzaneh Shahin Varnoosfaderani, Jayashri Mahalingam, Jianping Liu, Olle Larsson, Outi Hovatta, Frank Gaunitz, Anita Göndör, Michael Andäng, Satish S Kitambi
ABSTRACT

Stem cells display a fundamentally different mechanism of proliferation control when compared to somatic cells. Uncovering these mechanisms would maximize the impact in drug discovery with a higher translational applicability. The unbiased approach used in phenotype-based drug discovery (PDD) programs can offer a unique opportunity to identify such novel biological phenomenon. Here, we describe an integrated phenotypic screening approach, employing a combination of

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Product Description

Sigma-Aldrich
meso-Tetraphenylporphyrin, BioReagent, suitable for fluorescence, ≥99.0% (HPLC)

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