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Boronic acid recognition of non-interacting carbohydrates for biomedical applications: increasing fluorescence signals of minimally interacting aldoses and sucralose.

Organic & biomolecular chemistry (2017-11-14)
Angel Resendez, Md Abdul Halim, Jasmeet Singh, Dominic-Luc Webb, Bakthan Singaram
ABSTRACT

To address carbohydrates that are commonly used in biomedical applications with low binding affinities for boronic acid based detection systems, two chemical modification methods were utilized to increase sensitivity. Modified carbohydrates were analyzed using a two component fluorescent probe based on boronic acid-appended viologen-HPTS (4,4'-o-BBV). Carbohydrates normally giving poor signals (fucose, l-rhamnose, xylose) were subjected to sodium borohydride (NaBH

MATERIALS
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Product Description

Sigma-Aldrich
8-Hydroxypyrene-1,3,6-trisulfonic acid trisodium salt, ≥96%