Protective effect of xanthohumol against age-related brain damage.

The Journal of nutritional biochemistry (2017-09-28)
Lisa Rancán, Sergio D Paredes, Irene García, Pedro Muñoz, Cruz García, Guzmán López de Hontanar, Mónica de la Fuente, Elena Vara, Jesús A F Tresguerres
ABSTRACT

It has been recently shown that xanthohumol, a flavonoid present in hops, possesses antioxidant, anti-inflammatory and chemopreventive properties. However, its role in the aging brain has not been addressed so far. Therefore, this study aimed to investigate the possible neuroprotective activity of xanthohumol against age-related inflammatory and apoptotic brain damage in male senescence-accelerated prone mice (SAMP8). Animals were divided into 4 groups: Untreated young mice, untreated old mice and old mice treated either with 1 mg kg

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Nitric oxide, 98.5%