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FFAR2-FFAR3 receptor heteromerization modulates short-chain fatty acid sensing.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology (2017-09-09)
Zhiwei Ang, Ding Xiong, Min Wu, Jeak Ling Ding
ABSTRACT

Free fatty acid receptors 2 and 3 (FFAR2/FFA2/GPR43 and FFAR3/FFA3/GPR41) are mammalian receptors for gut microbiota-derived short-chain fatty acids (SCFAs). These receptors are promising drug targets for obesity, colitis, colon cancer, asthma, and arthritis. Here, we demonstrate that FFAR2 and FFAR3 interact to form a heteromer in primary human monocytes and macrophages

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Duolink® In Situ PLA® Probe Anti-Rabbit PLUS, Affinity purified Donkey anti-Rabbit IgG (H+L)
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Duolink® In Situ PLA® Probe Anti-Mouse MINUS, Affinity purified Donkey anti-Mouse IgG (H+L)
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Duolink® In Situ Detection Reagents Brightfield

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