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Simple, Efficient Protocols for the Pd-Catalyzed Cross-Coupling Reaction of Aryl Chlorides and Dimethylamine.

Tetrahedron letters (2009-07-01)
Brian K Lee, Mark R Biscoe, Stephen L Buchwald
ABSTRACT

Simple and efficient procedures for the Pd-catalyzed cross-coupling reaction of aryl chlorides and dimethylamine are described. At room temperature with a strong base, t-BuXPhos is employed as the supporting ligand; at 110 °C with a weak base, XPhos is employed as the supporting ligand. In each of these cases, commercially available solutions constitute the source of the dimethylamine, and recently disclosed precatalysts constitute the source of the ligand and Pd. This work further expands the utility of these precatalysts in reactions that benefit from an easily activated source of L(1)Pd(0).

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
XPhos Pd G1
Sigma-Aldrich
tBuXPhos Pd G1