MilliporeSigma
  • Home
  • Search Results
  • In vitro apoptotic mechanism of a novel synthetic Quinazolinyl derivative: Induces caspase-dependent intrinsic pathway on THP-1, leukemia cell line.

In vitro apoptotic mechanism of a novel synthetic Quinazolinyl derivative: Induces caspase-dependent intrinsic pathway on THP-1, leukemia cell line.

Chemico-biological interactions (2017-12-12)
Sridhar Vakamullu, S K Arepalli, L R Velatooru, Venkateswara Rao J, Kavin Kennedy P, Narsaiah B
ABSTRACT

Several quinazoline derivatives have been found to possess a broad spectrum of biological activities. Previously our research group has synthesized and studied the anti-proliferative effects of N-Decyl-N-(2-Methyl-4-Quinazolinyl) Amine (DMQA). The current study evaluated the cytotoxic and apoptotic properties of DMQA in THP-1 cells. The cytotoxic potential of DMQA was assessed using MTT assay on a panel of cancer cell lines which include HeLa, Mia PaCa-2, A 375, B16-F10, A 549,A 431, U937, THP-1, HL-60 and peripheral blood mononuclear cells (PBMC's). Preliminary data revealed that the highest cytotoxic activity was against THP-1 leukemia cell line (IC

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
6-Carboxyfluorescein diacetate, ~95% (HPLC)
Sigma-Aldrich
JC-1, solid