CHIROBIOTIC phases are based on covalently bonding macrocyclic glycoproteins to a high purity 5 micron silica gel in such a way as to establish it’s stability while retaining essential components for chiral recognition. CHIROBIOTIC V and V2 are based on bonding Vancomycin, which contains 18 chiral centers surrounding three pockets or cavities. Five aromatic ring structures bridge these strategic cavities. Hydrogen donor acceptor sites are readily available close to the ring structures. CHIROBIOTIC V has demonstrated selectivity similar to glycoprotein phases except it is stable from 0-100% organic modifier and exhibits high sample capacity.
For CHIROBIOTIC V2, changes to the linkage chemistry and silica offer improvements for preparative LC and for more demanding chiral separations. CHIROBIOTIC T, T2, and TAG are based on bonding the amphoteric glycopeptide, Teicoplanin, which contains 23 chiral centers surrounding four pockets or cavities. For CHIROBIOTIC T2, changes to the linkage chemistry and silica offer improvements for preparative LC and for more demanding chiral separations. CHIROBIOTIC TAG has the sugars removed from the macrocyclic glycopeptide to produce an aglycone structure as a variant of CHIROBIOTIC T. CHIROBIOTIC R is based on bonding Ristocetin A to high purity 5 micron silica.
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