CYCLOBOND is the name given to Astec technology for bonding cyclodextrins to a high purity silica gel through a stable ether linkage. Introduced in 1983, this patented stationary phase retains ability to form inclusion complexes, and allows for numerous chemical separations by selectively including into the cyclodextrin cavity, from solution, a wide variety of organic molecules. CYCLOBOND I are β-cyclodextrin bonded and CYCLOBOND II are γ-cyclodextrin bonded.
CYCLOBOND I 2000 series of HPLC columns is specially formulated to meet today’s stringent requirements for analysis in the pharmaceutical industry, and for small analytes of general interest in the chemical and environmental areas. Astec has focused on the need to accurately and reproducibly separate enantiomers. The result is a high performance range of chiral separation phases with guaranteed batch to batch reproducibility, greater stability and improved selectivity and resolution. Based on the original CYCLOBOND I (β-cyclodextrin) columns, the CYCLOBOND I 2000 series are second-generation products. The native β-cyclodextrin and eight β-cyclodextrin derivatives are in the CYCLOBOND I 2000 series.
CYCLOBOND II series columns are excellent chiral selectors for multi-ring structures such as those based on anthracene, chrysene or pyrene. These are γ-cyclodextrin bonded phases, and consist of 8 glucopyranose units arranged in the same truncated cone shape. Applications include steroids, porphorins, FMOC amino acids. Applications for CYCLOBOND II AC, an acetylated derivative, include napthylethylamine, steroids, and sterols.
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