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HomeSmall Molecule HPLCHigh-Purity Solvents: UHPLC-MS, LC-MS, & HPLC Instrumental Analyses

High-Purity Solvents: UHPLC-MS, LC-MS, & HPLC Instrumental Analyses

High-purity solvents

We are committed to providing our customers with the widest selection of high-purity solvents, specifically designed to deliver ultimate performance in UHPLC-MS, LC-MS, and HPLC Instrumental Analysis. In agreement with our commitment, we offer solvents under two premium brands: LiChrosolv® solvents and OmniSolv® solvents (only in the US and Canada) under the Supelco® portfolio for regulated/accredited application fields and SigmaAldrich® portfolio for research fields. Our large portfolios of analytical solvents allow for reliable, accurate, and reproducible results without demanding costly purification and repeated analyses. Also, our latest advancement in purification technology reaches a new quality milestone in the category of high-purity solvents, thereby enabling accurate and reproducible results.

Portfolio BrandGradesApplications PackagingFeatures
Supelco® LiChrosolv® & OmniSolv® (NA) SigmaAldrich®  HPLC SolventsHPLC-UV
  • Amber bottles
  • Aluminum bottles
  • Recyclers
  • Microfiltered (0.2 μm)
  • Extensive QC testing ensures lot-to-lot consistency
Supelco® LiChrosolv®, & OmniSolv® (NA) SigmaAldrich®  HPLC Isocratic SolventsHPLC Isocratic elution
  • Amber bottles
  • Aluminum bottles
  • Recyclers
  • Microfiltered (0.2 μm)
  • Low UV profile
  • LC Isocratic suitible; tested for use in LC-UV applications
  • Lot-to-lot consistency
Supelco® LiChrosolv®, & OmniSolv® (NA) SigmaAldrich®  HPLC Gradient SolventsHPLC Gradient elution
  • Amber bottles
  • Aluminum bottles
  • Recyclers
  • Microfiltered (0.2 μm)
  • Low UV profile
  • Low impurity gradient LC baseline
  • No interferences
  • Lot-to-lot consistency  
Supelco® & OmniSolv® (NA) SigmaAldrich®  HPLC Plus SolventsHPLC gradient, UV and GC residue analysis
  • Amber bottles
  • Recyclers
  • Microfiltered (0.2 μm) Low UV profile for use near a solvent’ UV cut off
  • High-purity & low gradient baseline drift specs meets demanding LC-UV and some LC-MS applications
  • Suitability tested for GC analysis
  • Low levels of particles and non-volatile impurities
Supelco® LiChrosolv®, & OmniSolv® NA)  LC-MS SolventsLC-MS/MS
  • Amber bottles
  • Recyclers
  • Microfiltered (0.2 μm)
  • Clean UV Impurity profile maximizes sensitivity near UV cut off
  • LC-MS suitability
  • Low particulates levels and non-volatile impurities increases the longevity of columns and systems.
  • Low levels of alkali metal impurities
  • Lot-to-lot consistency
Supelco® LiChrosolv®, SigmaAldrich®  UHPLC-MS SolventsUHPLC-MS/MS &UHPLC-UV
  • Borosilicate bottles
  • Microfiltered (0.2 μm)-No increase in back pressure due to the solvent
  • Extremely low detection limits using any detection mode
  • Suitability tested by UHPLC-UV/MS & UHPLC-MS TOF with the tightest specification for both positive & negative MS modes.
  • High-purity for extremely low detection limits under any detection mode
  • Extremely low baseline with a minimum of impurity peaks e.g. phthalates and PEG
  • Minimum MS-adduct formation caused by leakage of alkali ions over time
  • Lot-to-lot reproducibility
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