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LC/MS Analysis of Antiarrhythmic Drugs and Metabolites on Ascentis® Express HILIC

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Small Molecule HPLC

LC/MS Analysis of Antiarrhythmic Drugs and Metabolites on Ascentis<sup>®</sup> Express HILIC

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The benefit of HILIC over traditional reversed-phase chromatography is two-fold for both sample introduction and analyte detection. First, the high acetonitrile concentration of HILIC mobile phases allows for direct analysis of precipitated plasma samples without the need for additional sample solvent exchange. Second, the high acetonitrile content provides increased analyte response in positive ESI MS detection. 