Collagen is the most abundant mammalian protein and the main component of connective tissues. Typically collagen is first synthesized as individual glycine-rich preprocollagen monomeric strands from the ribosomes in the rough endoplasmic reticulum (RER). After transport to the lumen of the RER signal peptides are cleaved to yield procollagen. Lysine and proline are hydroxylated and glycosylated in the lumen and a helix composed of three peptides is formed. It is then transported to the Golgi and excreted from the cell by exocytosis. Procollagen's propetides are then removed to yield tropocollagen which may join together to form fibrils. The "collagen type" designations of Bornstein and Traub is determined by the peptide composition of the triple helix.

Collagen Type Specific Diagrams

Collagen
Collagen Type specific diagrams

Collagen Type specific diagram

Social Media

LinkedIn icon
Twitter icon
Facebook Icon
Instagram Icon

MilliporeSigma

Research. Development. Production.

We are a leading supplier to the global Life Science industry with solutions and services for research, biotechnology development and production, and pharmaceutical drug therapy development and production.

© 2021 Merck KGaA, Darmstadt, Germany and/or its affiliates. All Rights Reserved.

Reproduction of any materials from the site is strictly forbidden without permission.