The Heck reaction is the palladium catalyzed cross-coupling reaction between alkenes, and aryl or vinyl halides (or triflates) to afford substituted alkenes.1,2 It is a useful carbon–carbon bond forming reaction with synthetic importance. The reaction proceeds in the presence of base and it is highly stereoselective in nature. The Heck reaction, discovered by Tsutomu Mizoroki and Richard F. Heck, is also referred to as the Mizoroki–Heck reaction.3 The Pd-catalyzed Mizoroki–Heck reaction of olefins with aryl halides has been recognized with a Nobel Prize in chemistry in 2010.4
Examples of the Heck reaction
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The Heck reaction is useful for the synthesis of:
Asymmetric Mizoroki Heck Reactions
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