Dehydrative condensation of carboxylic acids and amines is the primary option for the synthesis of amides. Given the ubiquitous nature of amide bond linkages, competent amidation catalysts have long been sought after for enabling general amide synthesis. A research group in the Institute of Microbial Chemistry (Tokyo) developed the Pym-DATB catalyst (901627) featuring a B3NO2 heterocycle, which engages a wide range of carboxylic acids and amines in amide bond formation.
Figure 1. Pym-DATB Amidation Catalyst (901627)
Reaction condition: catalyst 1 - 5 mol% in PhF or toluene
Figure 2.Scope of Pym-DATB Catalyst
＊The use of toluene with Dean-Stalk apparatus can obviate the use of molecular sieves.
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